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Updated: Jul 19, 2025
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对口腔状细胞癌的潜在分子机制和预后标记物的鉴定:生物信息学分析
Suthipong Chujan1, Nakarin Kitkumthorn2, Jutamaad Satayavivad1
1Laboratory of Pharmacology, Chulabhorn Research Institute, Bangkok, Thailand.
概括
包括IRF4和CCR7在内的五个枢纽基因被确定为口腔癌的关键预后指标. 它们的表达水平与患者生存和免疫细胞透相关,提供潜在的治疗点.
科学领域:
- 在瘤学瘤学.
- 生物信息学是一种生物信息学.
- 免疫学 免疫学 免疫学
背景情况:
- 口腔状细胞癌 (OSCC) 构成了重大的健康挑战,需要改进治疗策略.
- 了解潜在的生化途径和预后指标对于有效的OSCC管理至关重要.
研究的目的:
- 在口腔癌中确定关键的生化途径,预后指标和治疗点.
- 增强口腔癌患者现有的治疗策略.
主要方法:
- 对五个基因表达综合数据集的生物信息分析,以识别差异表达基因 (DEG).
- 对DEG进行了基因本体学 (GO) 和KEGG通路分析.
- 用蛋白与蛋白相互作用 (PPI) 网络分析来识别枢纽基因.
- 核心基因的预后值和免疫细胞透相关性被评估使用数据库,如人类蛋白质图谱 (HPA) 和TIMER.
主要成果:
- 总共有2071个上调和1893个下调的基因被确定.
- 在免疫反应和炎症性细胞因子相互作用途径中,DEGs被显著丰富.
- 五个枢纽基因 (IRF4,CCR7,TNFRSF17,CD27,S1PR4) 被确定在OSCC中至关重要.
- 这些枢纽基因被预测为有利的预后标记,较低的表达与较差的整体存活率相关.
- 枢纽基因表达与OSCC瘤中的各种免疫细胞透类型有显著的相关性.
结论:
- 炎症和免疫反应在OSCC的发病过程中是至关重要的.
- 这五个已识别的枢纽基因是OSCC预后的强有力的预测因素.
- 这些枢纽基因代表了潜在的治疗点和口腔癌的诊断标记.
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