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脑恶性瘤中的B7-H3:免疫学和免疫疗法

Xiaopeng Guo1, Mengqi Chang1,2, Yu Wang1

  • 1Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

International journal of biological sciences
|August 11, 2023
PubMed
概括

B7-H3 (CD276) 是一个有前途的免疫治疗对脑癌的目标. 阻断B7-H3显示有潜力改善抗瘤反应和治疗棘手的大脑瘤,如质母细胞瘤.

关键词:
B7-H3 B7-H3 B7-H3 B7-H3 B7-H3 B7-H3 B7-H3 B7-H3 B7-H3 B7-H3 B7-H3 B7-H3抗体与药物的联合疗法是抗体与药物的联合疗法.大脑瘤是个大脑瘤癌症免疫疗法免疫疗法仿制性抗原受体T细胞疗法T细胞疗法瘤微环境是一个微环境.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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