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氨酸N-甲基转移酶SETD7通过STAT3/PD-L1级联促进膀癌的进展和免疫逃脱

Jiancheng Lv¹, Qikai Wu¹, Kai Li¹

¹Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

International journal of biological sciences

|August 11, 2023

概括

氨酸甲基转移酶SETD7通过上调PD-L1.1,促进膀癌的进展和免疫逃生. 准SETD7可能会改善膀癌患者的免疫疗法.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

膀癌 (BCa) 免疫疗法敏感性有限.
蛋白质甲基化在癌症中的作用正在出现.
在BCa进展和免疫逃避中SETD7的功能值得研究.

研究的目的:

研究氨酸N-甲基转移酶SETD7在膀癌中的作用.
探索SETD7对BCa进展和免疫逃逸的影响.
确定SETD7作为BCa诊断和治疗的潜在生物标志物.

主要方法:

在BCa.中分析SETD7表达及其与预后和免疫治疗敏感性的相关性.
在体外测试 (繁殖,迁移,共同培养) 和体内 (HuNOG小鼠) 实验.
使用分子技术验证SETD7/STAT3/PD-L1信号通路.

主要成果:

在BCa中,SETD7的表达很高,这与预后不佳和高级等级有关.
SETD7促进BCa细胞的增殖和迁移.
SETD7抑制CD8+T细胞活动,并通过SETD7/STAT3/PD-L1轴促进免疫逃生.

结论:

SETD7驱动BCa的进展和免疫逃避.
SETD7是预测BCa预后的潜在生物标志物.
在增强BCa免疫疗法方面,SETD7是一个有前途的治疗标.

关键词:

在SETD7中,SETD7是SETD7.膀癌:膀癌是一种癌症.免疫系统的逃脱是免疫逃脱.移民移民迁移迁移它们的扩散和扩散.

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