干细胞在耳部软骨再生中的应用和进展:系统性审查
Yu Liu1,2, Wenqing Wu1, Chun Seunggi1
1Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, China.
Frontiers in cell and developmental biology
|August 11, 2023
概括
脂肪衍生干细胞 (ADSCs) 等干细胞显示出通过再生软骨来进行耳朵重建的前景. 虽然在体外和动物模型中有效,但用于耳膜重建的临床应用需要进一步的研究和大型动物研究.
科学领域:
- 再生医学是一种再生医学.
- 生物材料科学 生物材料科学
- 整形和重建手术 整形和重建手术
背景情况:
- 微和获得的耳朵形的手术重建带来了重大挑战,特别是在创建合适的软骨支架.
- 干细胞具有多能分化能力,对于开发软骨支架至关重要,是耳朵重建研究的重点.
研究的目的:
- 审查和总结关于使用干细胞用于耳部软骨重建的研究.
- 识别干细胞的类型,体生成的方法,以及组织工程耳软骨的结果.
主要方法:
- 在PubMed,MEDLINE,Cochrane和Ovid数据库中对2005年至2023年间发表的文章进行了全面的文献搜索.
- 关键词包括干细胞,耳膜软骨,耳膜软骨,状软骨,耳膜重建,冠状细胞再生和组织工程.
- 选择和分析了33篇相关的同行评审文章.
主要成果:
- 脂质衍生干细胞 (ADSC),骨髓介质干细胞 (BMMSC),周心体干细胞/原始细胞 (PPC) 和软骨干细胞/原始细胞 (CSPC) 是主要的干细胞来源,用于冠状细胞再生.
- 方法包括直接注射到软骨中,与耳膜细胞共同培养,以及体外冠状元诱导.
- 干细胞在试验室中表现出原体潜力,并在体内植入后保持弹性和形态.
结论:
- ADSCs,BMMSCs,PPCs和CSPCs是用于面软骨重建的关键干细胞.
- 再生软骨表现出与本地软骨相似的特性,经过对aggrecan (AGA) 和II型原蛋白的测试证实了这一点.
- 使用干细胞进行耳朵重建处于动物实验的早期阶段,缺乏大型动物移植数据,表明需要进一步开发.
相关概念视频
Stem Cell Therapy for Tissue Regeneration
4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
Stem Cell Culture
5.2K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.2K
Mesenchymal Stem Cells
4.8K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.8K
Tissue Renewal without Stem Cells
1.7K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...
1.7K
iPS Cell Differentiation
2.7K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.7K


