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SARS-CoV-2 感染和疫苗接种对炎症性关节炎的影响:一个队列研究
Giovanni Striani1, Ariela Hoxha2, Mariagrazia Lorenzin1
1Rheumatology Unit, Department of Medicine (DIMED), University of Padua, Padua, Italy.
Frontiers in immunology
|August 11, 2023
概括
患有炎症性关节炎 (IA) 的患者在感染SARS-CoV-2后经历了显著更多的爆发. 虽然疫苗的副作用很常见,但在这种IA队列中,接种疫苗后的关节炎爆发并不具有统计学意义.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性关节炎 (IA) 患者在感染和接种疫苗方面面临独特的挑战.
- 了解SARS-CoV-2及其疫苗对IA的影响对于患者管理至关重要.
研究的目的:
- 评估SARS-CoV-2感染对IA患者的影响.
- 在IA中评估SARS-CoV-2疫苗的短期和长期不良事件 (AE).
- 确定感染和接种疫苗后关节炎爆发的发生率.
主要方法:
- 对362名IA患者 (风湿性关节炎,牛皮性关节炎,性脊柱炎) 和165名健康对照 (HC) 的回顾性队列研究.
- 收集关于SARS-CoV-2感染,疫苗接种情况,AE和疾病爆发的数据.
- 在感染和接种疫苗后一个月内分析IA爆发率.
主要成果:
- 32.3%的IA患者感染了SARS-CoV-2,其中34.2%经历了爆发;7.5%需要改变治疗.
- 91.4%的IA患者至少接种了一剂疫苗.
- 30.8%的人报告了疫苗的副作用;15.7%的多剂量患者经历了爆发,23.1%需要改变治疗.
结论:
- SARS-CoV-2 感染显著增加了 IA 爆发率.
- 虽然IA爆发发生在接种疫苗后,但这种关联在统计学上并不显著.
- 对IA患者需要进一步监测感染和疫苗接种结果.
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