在COVID-19患者中,IL6的高表达和免疫细胞的减少与心肌损伤相结合
Tingting Chen1, Haixin Chen2, Ping Chen1
1Medical Laboratory, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.
Frontiers in immunology
|August 11, 2023
概括
升高的干白素-6 (IL6) 水平和淋巴细胞数量减少与COVID-19患者的心肌损伤有关. IL6可能通过互白素信号通路驱动这种损伤,提供潜在的治疗点.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 心肌损伤是2019年冠状病毒病 (COVID-19) 的重要并发症,导致不良后果.
- 鉴定COVID-19相关心肌损伤中的关键调节分子对于开发有效的治疗方法和改善患者预后至关重要.
研究的目的:
- 确定关键的调节分子和涉及COVID-19相关的心肌损伤的途径.
- 在COVID-19患者中探索特定分子标记物,免疫细胞种群和心肌损伤之间的关系.
主要方法:
- 利用基因组丰富分析 (GSEA) 识别共同调节途径并选差异表达基因 (DEGs).
- 构建了一个蛋白质与蛋白质相互作用 (PPI) 网络,以识别关键的调节基因,并在多个数据集中验证发现.
- 分析了267名COVID-19患者的临床数据,包括高灵敏度热素 (hsTnI) 水平,互白素-6 (IL6) 表达和淋巴细胞子集.
主要成果:
- 鉴定出互白素信号通路和GPCR连接体结合是COVID-19相关心肌损伤中的共同调节通路.
- 包括IL6在内的7个关键基因被确定,这些基因可以区分心肌损伤患者和没有心肌损伤的患者.
- 患有心肌损伤的COVID-19患者表现出IL6水平升高和CD4+T细胞,CD8+T细胞,B细胞和NK细胞数量减少.
结论:
- 在COVID-19中心肌损伤与增加IL6表达和减少淋巴细胞数量有关.
- 干白素-6 (IL6) 可能在通过干白素信号通路调解心肌损伤方面发挥作用.
- 研究结果表明,IL6和相关途径是COVID-19心肌损伤患者治疗干预的潜在目标.
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