从聚焦超声波切除的T淋巴细胞随后在采用细胞转移免疫疗法后调解细胞抗瘤免疫力
Li-Feng Ran1,2, Xun-Peng Xie2,3, Ji-Zhu Xia2
1Clinical HIFU Center for Tumor Therapy, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Frontiers in immunology
|August 11, 2023
概括
高强度聚焦超声波 (HIFU) 刺激T细胞,增强它们对抗瘤的能力. 从接受HIFU治疗的小鼠中采用这些T细胞的转移显著提高了抗瘤免疫力和瘤细胞亡.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 生物技术是生物技术.
背景情况:
- 以前的研究表明,高强度聚焦超声波 (HIFU) 在小鼠H22瘤模型中刺激瘤特异性T细胞.
- 从接受HIFU治疗的小鼠中采用T细胞的转移抑制了瘤的生长和进展.
研究的目的:
- 研究T细胞在HIFU介导免疫调节中的机制.
- 阐明T细胞在针对癌症治疗的聚焦超声波切除中的作用.
主要方法:
- 在60只H22瘤携带的小鼠中进行HIFU或假HIFU治疗; 30只幼稚的小鼠作为对照.
- 在治疗后14天收集的脏T细胞悬浮液.
- 从接受HIFU治疗的小鼠中采用1x10^6 T细胞转移到携带瘤的小鼠中,随后进行免疫学评估.
主要成果:
- 接受HIFU治疗的小鼠的T细胞显著增强了细胞毒性T淋巴细胞 (CTL) 活性,TNF-α和IFN-γ分泌.
- 在HIFU组中观察到瘤透淋巴细胞 (TILs) 和 H22瘤细胞的Fas连接体+和穿孔素+数量增加.
- 在瘤细胞和Fas连接体+和穿孔素+TILs之间发现了线性相关性.
结论:
- 来自接受HIFU治疗的小鼠的T细胞介导细胞抗瘤免疫.
- 这些T细胞在基于HIFU的癌症治疗免疫调节中起着至关重要的作用.
关键词:
剥离 剥离 剥离 剥离收养细胞转移的收养细胞转移灭症 (apoptosis) 是一种死亡的过程.细胞毒性T淋巴细胞高强度聚焦超声波高强度聚焦超声波免疫调节 免疫调节 免疫调节免疫疗法 免疫疗法肝癌 肝癌 是一种肝癌.更多相关视频
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