通过使用德克斯梅托米丁,胺或盐水进行术前雾化来减少术后喉疼痛:一项前性随机对照试验
Amanta L Ittoop1, Priyanka Gupta1, Gaurav Jain1
1Department of Anaesthesiology, 6 Level, Medical College Building, All India Institute of Medical Sciences (A. I. I. M. S), Rishikesh, Uttarakhand, India.
Journal of anaesthesiology, clinical pharmacology
|August 11, 2023
概括
术前使用德克斯梅德托米丁雾化显著降低了全身麻醉后术后喉疼痛 (POST) 的发生率和严重程度. 与盐水相比,胺也显示出减少的趋势,但德克斯梅德托米丁更有效.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 手术后喉痛 (POST) 是全身麻醉后的一个常见并发症.
- 关于术前雾化用德克斯梅托米丁或胺治疗POST的疗效的文献是有限的.
研究的目的:
- 为了比较手术前雾化与德克斯梅托米丁,胺或盐水对POST发生率和严重性的影响.
主要方法:
- 132名美国麻醉学会 (ASA) 的I-II级患者接受了可选腹腔镜手术,被随机分为三组.
- 组在全身麻醉之前接受了 nebulized dexmedetomidine (D), ketamine (K) 或盐水 (C).
- 术后发病率和严重程度通过对患者的采访在术后2,6,12和24小时进行评估.
主要成果:
- 与K (54.5%) 和C (56.8%) 组相比,D组的POST发病率 (29.5%) 和2小时后的严重程度明显较低.
- 这种趋势在术后6小时持续存在.
- 平均动脉压在D组中在手术期间和手术后立即显著降低. 手术后镇静,恶心和吐在两组之间没有显著差异.
结论:
- 术前用德克斯梅德托米丁雾化有效地减少了早期POST的发生率和严重程度.
- 德克斯梅德托米丁似乎是缓解POST的有希望的药物.
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