相关实验视频
Updated: Jul 19, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
65岁以上的中国成年人甲状腺自身免疫和甲状腺功能低下之间的年龄特定关联:一个横截面研究
Mengjie Zhang1,2, Wenjing Ni1,2, Lina Zhang1,2
1Endocrine and Diabetes Center, The Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
甲状腺自身免疫性疾病是老年人甲状腺功能低下症的重要危险因素. 然而,在80岁及以上的个体中,这种关联会减弱,这表明年龄特定的相关性.
科学领域:
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
- 流行病学 流行病学
背景情况:
- 甲状腺自身免疫性疾病 (TAI) 和老年人甲状腺功能低下症之间的关系还不清楚.
- 甲状腺功能低下症,包括亚临床 (Shypo) 和明显 (Ohypo) 形式,在老年人群中很普遍.
研究的目的:
- 在充足的地区,研究65岁及以上个体中甲状腺功能低下症的流行病学特征.
- 确定老年人群中不同年龄组的TAI和甲状腺功能低下之间的相关性.
主要方法:
- 一项涉及中国约充足地区2443名老年人 (≥65岁) 的横截面研究.
- 参与者分为65-69岁,70-79岁和80岁以上的年龄组.
- 数据收集包括问卷,体检,实验室测试和甲状腺超声波;使用二进制逻辑回归分析风险因素.
主要成果:
- 在老年人中,甲状腺功能低下的患病率随着年龄的增长而增加.
- TAI被确定为Shypo (OR, 1.94) 和Ohypo (OR, 7.64) 的风险因素.
- 在年轻的老年人群中观察到TAI和甲状腺功能低下之间的显著相关性,但在80岁以上的老年人群中没有.
结论:
- 低甲状腺症,特别是Shypo,在来自充足地区的中国老年人中很常见.
- 在老年人中,TAI是甲状腺功能低下的危险因素,相关性因年龄而异.
- TAI和甲状腺功能低下之间的关联是年龄特定的,在最年长的年龄组 (≥80岁) 减少.
更多相关视频
05:41Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
Published on: February 9, 2024
06:50A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
Published on: May 29, 2020
相关概念视频
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Psychoneuroimmunology: Diabetes and Cancer