Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

131
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
131
Information Processing Approach01:30

Information Processing Approach

77
The information-processing theory of cognitive development centers on fundamental mental processes, including attention, memory, and problem-solving skills. Researchers in this field examine how cognitive abilities, such as working memory, evolve and influence children's overall development. Studies indicate that children with stronger working memory tend to excel in reading comprehension, math, and problem-solving compared to peers with less efficient memory skills. Low working memory is...
77
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

161
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
161
Working Memory01:24

Working Memory

375
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
375
Oppositional Defiant Disorder01:30

Oppositional Defiant Disorder

83
A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
83
Intellectual Disability01:29

Intellectual Disability

117
Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
117

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Associations between sociodemographic factors and neighborhood opportunity with genetic service utilization in pediatric patients with neurofibromatosis type 1.

The Clinical neuropsychologist·2026
Same author

Associations between long-term hair cortisol levels and executive functioning in Wiedemann-Steiner Syndrome.

Neuropsychology·2026
Same author

Mapping Brain Metabolites in Tuberous Sclerosis Complex: A 3T MR Spectroscopic Imaging Study.

AJNR. American journal of neuroradiology·2026
Same author

Towards Characterizing the Developmental and Behavioral Profiles of ODLURO Syndrome: Shared Features With Wiedemann-Steiner Syndrome and Kabuki Syndrome.

Clinical genetics·2025
Same author

An HNRNPK-specific DNA methylation signature makes sense of missense variants and expands the phenotypic spectrum of Au-Kline syndrome.

American journal of human genetics·2025
Same author

Academic Learning Profiles Across Disorders of KMT2 Gene Family: Superimposed and Distinct Features Across Kabuki, Wiedemann-Steiner and ODLURO Syndromes.

Journal of intellectual disability research : JIDR·2025

相关实验视频

Updated: Jul 19, 2025

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
05:32

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

9.0K

在Wiedemann-Steiner综合征中,执行功能,行为功能和适应性功能困难之间的关联.

Rowena Ng1,2, Hans Tomas Bjornsson3,4,5,6, Jill A Fahrner3,4

  • 1Kennedy Krieger Institute, Baltimore, MD, USA.

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
|August 11, 2023
PubMed
概括

患有Wiedemann-Steiner综合征 (WSS) 的人经常经历执行功能 (EF) 缺陷,过度活跃和情绪失调. 认知灵活性和情绪控制是影响WSS患者行为和适应性功能的关键因素.

关键词:
行为调节 行为调节认知灵活性 认知灵活性情绪调节 情绪调节执行控制 执行控制在 KMT2A 中.维德曼·施泰纳综合征 维德曼·施泰纳综合征

更多相关视频

Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties
12:55

Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties

Published on: September 27, 2020

8.5K
Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

16.6K

相关实验视频

Last Updated: Jul 19, 2025

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
05:32

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

9.0K
Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties
12:55

Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties

Published on: September 27, 2020

8.5K
Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

16.6K

科学领域:

  • 神经遗传学 神经遗传学
  • 神经发育障碍 神经发育障碍
  • 行为科学 行为科学

背景情况:

  • 维德曼-施泰纳综合征 (WSS) 是一种罕见的神经遗传疾病,与KMT2A基因变异有关.
  • 现有研究表明,WSS可能与增加的焦虑和行为调节问题有关.
  • 综合性神经行为现象型的WSS仍然不完全理解.

研究的目的:

  • 调查WSS患者的执行功能 (EF) 概况.
  • 在WSS中检查执行功能和行为/适应性功能之间的关系.
  • 识别可能预测行为和适应性困难的特定EF挑战.

主要方法:

  • 使用了护理人员报告库存:执行职能行为评级库存第二版 (BRIEF-2),适应性行为评估第三版 (ABAS-3),以及优势和困难问卷 (SDQ).
  • 这项研究包括24名WSS患者 (平均年龄为10.68岁).
  • 统计分析包括相关性和层次线性回归来评估EF,适应性行为和情绪调节之间的关联.

主要成果:

  • 显著比例的WSS患者在执行功能方面表现出临床困难 (63%在BRIEF-2).
  • 在SDQ上报告了高水平的多动性 (75%) 和情绪问题 (54%).
  • 认知灵活性缺陷 (BRIEF-2 转变) 预测了情绪问题,情绪控制困难与适应性缺陷有关.

结论:

  • 患有WSS的个体存在执行功能缺陷,多动和情绪失调的风险较高.
  • 执行功能,特别是认知灵活性和情绪控制,与适应性和情感行为有显著的相关性.
  • 专注于认知灵活性和情绪调节的有针对性的行为干预措施显示出改善WSS结果的希望.