产前和产后暴露于NO2和婴儿快速体重增加 - 一个基于人口的队列研究
Neora Alterman1, Iaroslav Youssim1, Daniel Nevo2
1Braun School of Public Health and Community Medicine, The Hebrew University at Jerusalem - Hadassah, Jerusalem, Israel.
Paediatric and perinatal epidemiology
|August 11, 2023
概括
在怀孕和婴儿早期暴露于与交通有关的空气污染,特别是二氧化 (NO2),与婴儿快速体重增加有关. 这种早期体重增加是儿童超重和肥胖的危险因素.
科学领域:
- 环境健康 环境健康
- 儿科 儿科 儿科
- 流行病学 流行病学
背景情况:
- 儿童超重和肥胖是一个重大的全球健康挑战.
- 婴儿快速体重增加是儿童超重的一个关键预测因素.
- 暴露于环境空气污染,特别是在怀孕期间,与婴儿快速体重增加的风险增加有关.
研究的目的:
- 调查产前和产后暴露于环境二氧化 (NO2),这是交通相关空气污染的标志物,与婴儿快速体重增加之间的关联.
- 为了确定NO2的临界暴露期及其对婴儿生长速度的影响.
主要方法:
- 在以色列中部 (2011-2019) 的474,136名婴儿进行了基于人口的队列研究.
- 怀孕期间和产后前四周的每周平均NO2度使用优化分散模型进行评估.
- 使用SITAR方法建模体重增长速度,快速体重增长被定义为速度的最高三分之一.
主要成果:
- 在怀孕期间增加的NO2暴露与1.02的相对风险 (95% CI 1.00, 1.04) 相关,即婴儿体重快速增加.
- 产后在生命的前四周NO2暴露也显示1.02的相对风险 (95%CI1.01,1.04) 快速体重增加.
- 产前NO2暴露风险的关键时期从怀孕中期延长到出生.
结论:
- 产前和产后暴露于高水平的与交通有关的空气污染 (NO2) 独立地与婴儿快速体重增加有关.
- 婴儿快速体重增加是儿童超重和肥胖发展的重要危险因素.
- 调查结果强调了减少空气污染暴露对婴儿健康和长期体重管理的重要性.
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