现场便携式检测芬太尼及其类似物:一项审查
Richard A Crocombe1, Greg Giuntini2, David W Schiering3,4
1Crocombe Spectroscopic Consulting, Winchester, Massachusetts, USA.
Journal of forensic sciences
|August 11, 2023
概括
现场检测芬太尼及其类似物对于预防过量死亡至关重要. 本文回顾了便携式光谱方法,包括色度测试和质谱,用于在现场识别这些合成阿片类药物.
科学领域:
- 法医科学 法医科学 法医科学
- 分析化学 分析化学
- 公共卫生 公共卫生
背景情况:
- 芬太尼及其类型对公众健康构成重大风险,原因是它们的高强度和过量服用的可能性.
- 现场检测这些合成阿片类药物对于急救人员和公共安全人员来说至关重要,以防止意外暴露和过量服用.
- 现有的危险物质便携式检测方法正在适应芬太尼和模拟识别.
研究的目的:
- 审查和描述用于检测和识别芬太尼及其类型的现场便携式光谱方法.
- 概述现场阿片类药物检测各种分析技术的原则,应用和局限性.
- 为使用这些仪器在现场环境中的非科学家操作人员提供实用信息.
主要方法:
- 自动色度测试,包括横向流量测试.
- 振动光谱:中红外 (MIR) 和拉曼光谱.
- 分离和检测技术:气色谱-质谱 (GC-MS),离子运动谱 (IMS) 和高压质谱 (HPMS).
主要成果:
- 这篇论文详细介绍了这些便携式方法在现场用于芬太尼和模拟检测的应用.
- 考虑复杂混合物的分析以及每个技术的检测极限.
- 突出了光谱数据库和算法对于准确识别的重要性.
结论:
- 便携式光谱方法为现场检测芬太尼及其类似物提供了可行的解决方案.
- 有效的现场识别需要适当的仪器仪表,频谱数据库和用户培训.
- 这些技术是加强公共安全和缓解阿片类药物危机的重要工具.
相关概念视频
Opioid Analgesics: Synthetic and Semisynthetic Opioids
335
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
335
Opioid Receptors: Overview
1.0K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
1.0K
Drug Concentrations: Measurements
405
Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
Plasma...
Plasma...
405
Parenteral Anesthetics: Overview
155
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
155
Gas Chromatography: Types of Detectors-II
416
In gas chromatography, different detectors are employed to meet specific analytical needs. These detectors are often categorized based on their detection mechanisms and the types of compounds they are best suited to analyze. Thermal Conductivity Detectors (TCD), Flame Ionization Detectors (FID), and Electron Capture Detectors (ECD) represent common categories, each with unique operating principles and applications. However, beyond these, several other detectors are designed for more specialized...
416


