益生菌用于治疗刺激性肠综合征:系统性审查和三级元分析
Min Chen1, Lu Yuan2, Chao-Rong Xie2
1Department of Colorectal Diseases, Hospital of Chengdu University of Traditional Chinese Medicine.
益生菌为刺激性肠综合征 (IBS) 症状提供短期益处,改善整体症状,腹痛和生活质量. 较短的治疗时间和Bacillus益生菌显示出最好的结果.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究的研究.
- 临床试验分析临床试验分析
背景情况:
- 以前的评论表明益生菌可能有益于刺激性肠综合征 (IBS),但缺乏全面的数据.
- 现有的系统审查存在局限性,包括试验不足和依赖数据.
- 之前没有确定益生菌在IBS治疗中的整体效果大小.
研究的目的:
- 进行三级元分析,以确定益生菌对IBS的整体影响.
- 确定影响益生菌对IBS疗效的潜在调节者.
- 在管理IBS症状时为益生菌提供强大的效果大小.
主要方法:
- 在MEDLINE,Embase和Web of Science系统搜索相关的随机对照试验 (RCT).
- 主要结局:改善了全球IBS症状严重程度.
- 二次结果:改善腹痛和生活质量,通过三级元分析使用标准化平均差异 (SMD) 进行分析.
主要成果:
- 对72个RCT的分析表明,益生菌对全球IBS症状 (SMD -0.55),腹部疼痛 (SMD -0.89) 和生活质量 (SMD 0.99) 有显著的益处.
- 较短的治疗持续时间 (少于4周) 与所有结果中的更大的效果大小有关.
- 与其他类型相比,细菌益生菌在腹痛方面表现出更好的改善.
结论:
- 益生菌对全球IBS症状产生短期,中等效果的效益.
- 治疗持续时间和益生菌类型是治疗疗效的显著调节者.
- 较短的治疗持续时间和Bacillus菌株与IBS管理的改善结果有关.
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