米菲普里斯诱导的甲状腺功能低下症
1Mount Sinai Medical Center, Miami Beach, Florida, USA.
Journal of investigative medicine high impact case reports
|August 11, 2023
概括
用于轻度自主皮质醇分泌的米费普里斯可能导致可逆性甲状腺功能低下症. 这一案例凸显了在使用这种药物治疗期间监测甲状腺功能测试 (TFT) 的重要性.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 药物可以影响甲状腺功能并导致甲状腺功能低下.
- 米费普里斯用于治疗轻度自主皮质醇分泌 (MACS).
- 甲状腺功能低下症不是米费普里斯常见的副作用.
研究的目的:
- 在接受米费普里斯顿治疗的患者中报告新发性甲状腺功能低下症的病例.
- 讨论米费普里斯和甲状腺功能低下症之间的潜在联系.
- 为了强调在米费普里斯顿治疗期间需要对甲状腺功能进行监测.
主要方法:
- 一个病例报告,一名71岁的女性患有MACS,接受了米费普里斯顿治疗.
- 对MACS和甲状腺功能低下的临床表现,体检和实验室检查.
- 在治疗前,治疗期间和治疗后对甲状腺功能测试 (TFT) 的监测.
主要成果:
- 患者在接受米费普里斯顿治疗时出现了新发性甲状腺功能低下症.
- 在停止服用米费普里斯后,甲状腺功能低下症得到缓解,TFTs正常化.
- 患者成功地接受了levothyroxine治疗,后来停止了药物使用.
结论:
- 米费普里斯可能会诱导可逆性甲状腺功能低下症,尽管机制尚不清楚.
- 这一案例强调了基线和随访TFT在接受米费普里斯的患者中的重要性.
- 临床医生应考虑在接受米费普里斯治疗的患者中监测甲状腺功能,特别是那些症状暗示甲状腺功能低下的患者.
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