在诊断2019年冠状病毒病 (COVID-19) 时从上和/或下呼吸道取样 - 来自丹麦队列研究的结果
Line Storm1,2, Mette Toftgaard Roensbo1, Simon Kok Jensen3
1Department of Clinical Microbiology, Aarhus University Hospital, Aarhus N, Denmark.
Infectious diseases (London, England)
|August 11, 2023
概括
下呼吸道症状可以指导对严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 的补充检测. 症状持续时间没有影响呼吸道样本中SARS-CoV-2测试阳性.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 传染性疾病 传染性疾病
- 诊断测试 诊断测试 诊断测试
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 在上下呼吸道复制.
- 了解影响SARS-CoV-2测试阳性的因素对于准确诊断至关重要.
研究的目的:
- 为了评估症状特征,持续时间和SARS-CoV-2测试阳性之间的关联,在上下呼吸道样本中对上下呼吸道样本进行测试.
- 为了确定下呼吸道症状是否可以指导补充测试策略.
主要方法:
- 对住院患者进行了回顾性队列研究,这些患者患有SARS-CoV-2.
- 在48小时内采集的上下呼吸道样本的分析.
- 症状数据与逆转录酶-聚合酶链反应 (RT-PCR) 试验结果的相关性.
主要成果:
- 在122名患者中,83%的样本在两种样本类型中呈阳性,5%仅在上呼吸道样本中呈阳性,11%仅在下呼吸道样本中呈阳性.
- 下呼吸道症状可以识别98%的需要补充检测的患者.
- 根据样本阳性,在患者组之间没有观察到症状持续时间的显著差异.
结论:
- 下呼吸道症状的存在可以有效地指导补充下呼吸道采样的必要性.
- 症状持续时间不是在上或下呼吸道样本中对SARS-CoV-2测试阳性的可靠预测指标.
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