盆地肌肉炼与或没有杜洛西丁用于前列腺切除术后尿失禁:一个回顾性单中心研究
Chang Seok Kang1, Dae Hyun Kim1, Jae Hwi Choi1
1Department of Urology, Gyeongsang National University Hospital, Gyeongsang National University, College of Medicine, Institute of Health Science, Jinju, Korea.
Medicine
|August 11, 2023
概括
联合盆地肌肉炼 (PFME) 和杜洛西丁为前列腺切除术后尿失禁 (PPUI) 恢复提供短期益处. 然而,与单独使用PFME相比,这种组合治疗没有显著的长期有效性.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 盆腔健康 盆腔健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 前列腺切除术后尿失禁 (PPUI) 是激进前列腺切除术 (RP) 后的一种常见并发症.
- 盆地肌肉运动 (PFME) 是PPUI的标准治疗方法.
- 药理学辅助正在探索,以提高恢复.
研究的目的:
- 评估PPUI恢复中联合PFME和duloxetine治疗的有效性.
- 为了比较单独的PFME和PFME与duloxetine之间的康复率.
主要方法:
- 一项前性研究包括了197名接受RP的患者.
- 参与者被分为两组:仅PFME和PFME每天服用杜洛西丁 (30mg).
- 在手术后的2周,3,6,9和12个月,用 count (≤1个/天) 来评估 incontinence.
主要成果:
- 结合PFME和杜洛西丁组在2周后显示出明显较低的失禁率 (P = .019).
- 在3个月后,两组之间没有观察到 significant 的失禁率差异.
- 在12个月的随访期内,两组都在禁欲方面呈现逐步改善.
结论:
- 联合PFME和duloxetine治疗为PPUI恢复提供了短期的好处.
- 杜洛西丁对PPUI的PFME单疗没有显著的长期优势.
- 在PFME期间短期服用duloxetine可能会被考虑为早期PPUI恢复.
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