在青少年中,正常范围内的肌酸酸酶水平与骨矿物质密度之间的关联
Zhenwei Wang1,2, Weibin Du1,2, Meichun Han1,2
1Research Institute of Orthopedics, The Affiliated Jiangnan Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Medicine
|August 11, 2023
概括
肌酸基酶 (CPK) 显示出与青少年骨矿物质密度 (BMD) 的积极关联. 在正常范围内较高的CPK水平可能表明这个年龄组的骨健康状况更好.
科学领域:
- 生物化学 生化学
- 儿科内分泌学 儿科内分泌学
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 在青少年中,肌酸酶 (CPK) 和骨矿物质密度 (BMD) 之间的关系尚未得到充分证实.
- 了解影响青少年骨健康的因素对于预防晚年骨质疏松症至关重要.
研究的目的:
- 调查12至19岁青少年肌酸化酶 (CPK) 水平与骨矿物质密度 (BMD) 之间的关联.
- 确定CPK是否可以作为青少年骨健康的潜在生物标志物.
主要方法:
- 采用2011年至2018年国家健康和营养检查调查 (NHANES) 数据进行的横截面研究.
- 包括1188名男性和1629名12至19岁的女性.
- 进行了多变量线性回归和子组分析,调整了各种人口,生活方式和生化因素.
主要成果:
- 在青少年中观察到肌酸化酶 (CPK) 水平与骨矿物质总密度 (BMD) 之间存在显著的正相关性.
- 在调整了多个混变量后,这种关联仍然很重要.
- 这种积极的关系在不同年龄组,性别和种族之间是一致的,在年长的青少年和男性中更为明显.
结论:
- 在正常范围内的肌酸化酶 (CPK) 水平与青少年的骨矿物质总密度 (BMD) 有积极关联.
- 在青少年人群中,CPK可能是评估骨健康的新且可访问的生物标志物.
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