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炎症性肠病中的循环和循环DNA:从致病源到潜在的分子疗法
Federica Di Vincenzo1,2, Ylenia Yadid2, Valentina Petito1
1IBD Unit, Centro di Malattie dell'Apparato Digerente (CeMAD), Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00168 Rome, Italy.
无细胞DNA (cfDNA) 和异染色体圆形DNA (eccDNA) 可能在炎症性肠病 (IBD) 发病过程中发挥作用. 本综述探讨了它们在IBD治疗中的参与和潜在的治疗应用.
科学领域:
- 胃肠道学和分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠道疾病 (IBD),包括克罗恩病 (CD) 和性结肠炎 (UC),是慢性胃肠道疾病,病因和发病因不明.
- 无细胞DNA (cfDNAs) 是循环的DNA片段,在各种疾病中越来越多地被研究,包括炎症状况.
- 异染色体圆形DNA (eccDNA) 是在真核生物中发现的核DNA分子,人们越来越关注它们在自身免疫和炎症疾病中的潜在作用.
研究的目的:
- 审查目前关于cfDNA和eccDNA在IBD中的作用的文献.
- 探索像中性粒细胞外细胞陷和外基因组在IBD病变发生过程中的结构的参与.
- 讨论潜在的分子疗法和药物输送系统,如纳米粒子,用于IBD治疗.
主要方法:
- 关于cfDNA,eccDNA,中性粒细胞外细胞陷,外体和IBD的研究的综合文献综述.
- 分析现有数据,将cfDNA和eccDNA与炎症和自身免疫过程联系起来.
- 探索涉及新型药物输送系统的治疗策略.
主要成果:
- CfDNA和eccDNA与各种人类疾病有关,包括炎症状况.
- 新出现的证据表明cfDNA和eccDNA在IBD病变发生过程中可能发挥作用.
- 在IBD和cfDNA/eccDNA参与的背景下,中性细胞外细胞陷和外体也被考虑.
结论:
- CfDNA和eccDNA是了解IBD病因和病原学的有前途的研究领域.
- 对这些循环DNA形式的进一步调查可能会揭示新的诊断生物标志物.
- 向cfDNA,eccDNA和相关结构为IBD的创新治疗干预提供了潜力.
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