减缓糖尿病病的进展
Olivia Blazek1, George L Bakris1
1Department of Medicine, American Heart Association Comprehensive Hypertension Center, The University of Chicago Medicine, Chicago, IL 60637, USA.
Cells
|August 11, 2023
概括
糖尿病病是末期病的主要原因,可以通过特定疗法减缓. 结合氨酸- ангиотензин- алдостерон系统阻断剂,SGLT2 抑制剂和芬,为脏和心血管结果提供最大的益处.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病病 (DKD) 是糖尿病的一个主要并发症,导致末期病和心血管风险增加.
- 自20世纪90年代以来的治疗进展主要集中在减缓DKD进展和缓解不良心血管结果.
研究的目的:
- 审查目前和新兴的治疗方法,以减缓糖尿病病的进展.
- 突出结合不同药物类别的附加效益,以获得最佳的患者结果.
主要方法:
- 对糖尿病病的批准和新兴药物治疗方法的审查.
- 对作用机制的分析,包括抗炎,抗纤维和血液动力学效应.
- 为最大限度的脏保护和心血管风险降低确定组合治疗策略.
主要成果:
- 列宁- ангиотензин- алдостерон系统阻断剂 (ACEi/ARBs),非类固醇矿物质皮质体受体对抗剂 (NS-MRA) (如芬),以及SGLT2抑制剂是关键疗法.
- 这些药物提供了互补的好处,减缓了DKD的进展,改善了心血管结果.
- 使用最大剂量的ACEi/ARB,低剂量的SGLT2抑制剂和芬的组合疗法构成了DKD的"治疗支柱".
结论:
- 组合疗法在治疗糖尿病病方面取得了重大进展.
- 未来的研究旨在扩大治疗选择,以使功能下降正常化并减少心血管死亡率.
- 新兴疗法,如葡萄糖类-1受体激动剂,显示出对结局的承诺.
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