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Updated: Jul 19, 2025

CD Spectroscopy to Study DNA-Protein Interactions
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多克索鲁比改变了基因组在活跃促进体周围的空间组织

Maria E Stefanova1,2, Elizabeth Ing-Simmons3,4, Stefan Stefanov5,6

  • 1Development and Disease Research Group, Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.

Cells
|August 11, 2023
PubMed
概括

基因毒性抗癌药物,如多克索鲁比,通过影响DNA相互作用和凝聚蛋白分布来改变人体细胞染色质结构,独立于基因表达变化. 这影响了基因组架构和DNA修复机制.

关键词:
在DSBs中使用DSBs.这就是Hi-C.在Top2中排名第一.化疗 化疗是一种化学疗法.德克索鲁比辛 (doxorubicin) 是一种药物.活动主办人 活动主办人

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