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Updated: Jul 19, 2025

Efficient Transcriptionally Controlled Plasmid Expression System for Investigation of the Stability of mRNA Transcripts in Primary Alveolar Epithelial Cells
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PAI-1 在II型膜上皮细胞中调节p53表达和衰老

Tapasi Rana1, Chunsun Jiang1, Sami Banerjee1

  • 1Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Cells
|August 11, 2023
PubMed
概括

血原激活剂抑制剂1 (PAI-1) 通过抑制蛋白酶体活性和肺细胞中的p53降解来促进细胞衰老. 这一发现影响了对衰老,肺纤维化和其他与衰老相关的疾病的理解.

关键词:
在ATII细胞衰老的过程中,PAI-1是PAI-1的第一个类型.p53降解降解的方法蛋白质酶体活动的活性.

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