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L116 在CSPα中的删除促进α-Synuclein聚合和神经退行

Tao Guo1, Jing Xiong1, Hongyan Feng2

  • 1Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.

Molecular neurobiology
|August 11, 2023
PubMed
概括

在DNAJC5基因的突变导致成人发作的神经元状脂菌 (ANCLs),导致帕金森症. 这种突变损害了囊链蛋白α (CSPα),促进了α-synuclein聚合和神经毒性.

关键词:
在DNAJC5中.神经元的seroid lipofuscinoses可能会发生.帕金森症 帕金森症斯纳雷 (Snare) 是一个小鸟.α-Synuclein 是一种蛋白质.

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