COVID-19封锁和中心早期青春期的速度
1Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
Journal of endocrinological investigation
|August 11, 2023
概括
由于COVID-19的封锁,女孩中部早熟青春期 (CPP) 的发生率几乎增加了三倍. 封锁后的诊断表明CPP是一种较温和的形式,具有较大的环境影响.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖健康 生殖健康
- 公共卫生 公共卫生
背景情况:
- 异常性中央早熟性青春期 (CPP) 是一种青春期比正常时间更早开始的情况.
- COVID-19 流行病和相关的封锁可能影响了儿童的发展和健康结果.
- 了解CPP发病率和特征的变化对于儿科内分泌学至关重要.
研究的目的:
- 为了比较COVID-19封锁之前和之后的异常性CPP的发病率.
- 为了确定在封锁之前和之后诊断的女孩之间的CPP特征的差异.
主要方法:
- 对49名患有异常性CPP的女孩 (30名在封锁前,19名在封锁后) 的回顾性分析.
- 收集并比较了耳科学资料,病史,体检,荷尔蒙评估,骨龄和骨盆超声波.
- 封锁前和封锁后的CPP群体之间的统计比较.
主要成果:
- 与前六年相比,CPP发病率在2020-2021年期间增加了近三倍.
- 锁定后的女孩表现出更早诊断的趋势和显著较低的下丘脑-垂体-阴茎轴激活.
- 锁定后的患者的骨年龄增加显著降低,卵巢激活减少,母亲在初潮时年龄较晚.
结论:
- 在封锁后,新型CPP诊断的数量显著增加.
- 调查结果表明,CPP的进展程度较低,环境对锁定后女孩的青春期时间的影响更大.
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