维生素D可以作为青少年类风湿性疾病的辅助疗法吗?
Maciej K Stawicki1, Paweł Abramowicz1, Gabriela Sokolowska2
1Department of Pediatrics, Rheumatology, Immunology, and Metabolic Bone Diseases, Medical University of Bialystok, University Children's Clinical Hospital in Bialystok, Waszyngtona Street 17, 15274, Bialystok, Poland.
Rheumatology international
|August 11, 2023
概括
维生素D可能在青少年类风湿性疾病 (JRD) 中发挥作用,在受影响的儿童中观察到较低水平. 然而,目前的证据不足以证实维生素D补充对JRD治疗的益处.
科学领域:
- 儿科 儿科 儿科
- 类风湿病学 类风湿病学
- 内分泌学 在内分泌学.
背景情况:
- 维生素D对骨健康和免疫功能至关重要.
- 低于最佳的维生素D (25氧维生素D [25(OH) D]) 水平与成人炎症和自身免疫性类风湿性疾病有关.
- 青少年类风湿性疾病 (JRDs) 对成长中的儿童构成重大挑战.
研究的目的:
- 审查维生素D在治疗选定的JRD中的潜在作用.
- 探索有关儿童类类风湿性疾病中维生素D补充的现有证据.
主要方法:
- 在2023年6月的Medline/PubMed,EMBASE和Scopus的综合文献搜索.
- 关键词包括"维生素D"和特定的JRD (例如,青少年异常性关节炎,青少年红斑狼).
- 专注于研究维生素D在JRD治疗中的补充作用.
主要成果:
- 观察性研究表明,在几个JRD中,血清25(OH) D水平较低,与较高的促炎细胞因子相关.
- 在JRD中补充维生素D的预防或治疗效果的证据由于RCT结果不一致,仍然没有确定性.
- 补充维生素D可能是有益的,但数据不足以得出最终的结论.
结论:
- 虽然在JRD中注意到维生素D水平较低,但缺乏对补充剂益处的明确证据.
- 需要进一步进行精心设计的随机对照试验,以确定维生素D在JRD中的作用.
- 根据指导方针鼓励补充维生素D是值得的,因为缺乏广泛的.
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