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Gökçen Kerimoğlu¹, Tuğba Arıcı², Ayşe Firuze Bıyık³

¹Department of Histology and Embryology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Türkiye. gkerimoglu@ktu.edu.tr.

International urology and nephrology

|August 11, 2023

概括

丁 (Pte) 可能防止由化疗药物环胺 (CYP) 引起的脏和膀损伤. 这项对大鼠的研究表明,Pte减少了氧化应激和组织损伤,这表明它可能具有治疗作用.

科学领域:

药理学和毒理学药理学和毒理学
自然产品化学自然产品化学
脏和泌尿学研究

背景情况:

环胺 (CYP) 是一种广泛使用的化疗剂,已知具有毒性和囊炎诱导的副作用.
氧化应激对由CYP引起的器官损伤起着重要作用.
固醇 (Pte) 是蓝中发现的天然化合物,其结构类似于白醇,并具有抗氧化特性.

研究的目的:

为了评估Pterostilbene (Pte) 在大鼠模型中对循环胺 (CYP) 诱导的毒性和出血性囊炎的潜在保护功效.
调查潜在的机制,特别是氧化应激标志物的调节.

主要方法:

21只雄性Sprague Dawley大鼠被分配到三个组:对照组,CYP诱导的毒性和CYP + Pte治疗.
Pte (40 mg/kg) 被口服14天,在第9天给予单次腹腔内CYP (200 mg/kg) 剂量.
收集脏和膀组织进行组织学和生化分析,包括氧化应激标志物和亡.

主要成果:

二显著降低了脏组织中CYP诱导的恶性甲,总氧化剂状态 (TOS) 和氧化应激指数 (OSI) 的增加.
Pte的使用导致脏中超氧化物脱酶水平增加.
在膀组织中,Pte降低了TOS,OSI和亡,同时也改善了CYP诱导的两个器官的组织病理损伤.

结论:

固醇在老鼠中显示出显著的保护作用,防止循环胺诱导的毒性和囊炎.
保护机制可能涉及氧化应激和亡的减弱.
Pte代表了一种有前途的天然化合物,可以缓解化疗引起的器官损伤.

关键词:

细胞灭亡 (apoptosis) 是一种死亡的过程.环酸胺的使用方法囊炎是一种囊炎.毒性毒性毒性氧化应激是一种氧化应激.聚乙烯 (Pterostilbene) 是一种制剂.

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