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COVID-19治疗剂:它们是否构成环境风险?
Violaine Desgens-Martin1, Arturo A Keller1
1Bren School of Environmental Science and Management, University of California at Santa Barbara, Santa Barbara, California 93106, United States.
这项研究评估了COVID-19药物remdesivir和甲对水生生物的环境风险. 预测的环境度明显低于生态毒性值,表明对水生生物的风险最小.
科学领域:
- 环境化学环境化学
- 生态毒理学 生态毒理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 随着COVID-19的流行,人们开始广泛使用抗病毒和抗炎药物,如雷梅西维尔和德克萨米他.
- 洛杉矶县的高住院率需要对这些药物带来的潜在环境风险进行评估.
研究的目的:
- 预测雷梅西维尔和德克萨米他的环境度 (PEC).
- 评估这些药物及其代谢物对水生生物的生态毒性风险.
- 确定疫情期间水生生态系统是否面临制药污染的风险.
主要方法:
- 利用ChemFate模型根据住院数据预测环境度.
- 雇员生态结构活动关系 (ECOSAR) 来估计生态毒性值.
- 将预测的环境度与对水生生物的预测无效度进行比较.
主要成果:
- 对水生生物的预测毒性值比预测的环境度高2到11个数量级.
- 雷梅西维尔和德克萨米他在环境中的最高预测度远低于预计会造成危害的水平.
- 在评估条件下,没有发现对水生生物的重大风险.
结论:
- 在洛杉矶县,水生生物对雷梅西维尔和甲的环境暴露不太可能受到它们的使用的影响.
- 建模工具对于初步的新药剂生态风险评估是有价值的.
- 使用了保守的假设,强调需要对药品进行持续的环境监测.
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