关于制定评估二级校准器认证参考材料可换性标准的建议
W Greg Miller1, Thomas Keller2, Jeffrey Budd3
1Department of Pathology, Virginia Commonwealth University, Richmond, VA, United States.
Clinical chemistry
|August 11, 2023
概括
建立可交换性评估的定量标准,确保认证的参考材料 (CRM) 是适合用于体外诊断医疗器械 (IVD-MDs) 的校准器. 这涉及定义相对于测量不确定性的最大允许的非可交换性偏差 (MANCB).
科学领域:
- 临床实验室科学 临床实验室科学
- 计量学 计量学 计量学
- 生物医学工程 生物医学工程
背景情况:
- 二级高级校准器必须证明与体外诊断医疗器械 (IVD-MD) 校准层次的临床样本的可交换性.
- 可交换性确保在所有测量过程中,参考材料和临床样本之间保持一致的数值关系.
- 现有的文献描述了评估通用性的程序,但需要一个定量标准.
研究的目的:
- 为建立一个定量标准来评估认证参考材料 (CRM) 的可交换性提供建议.
- 为了定义一个标准,最大允许的非可交换性偏差 (MANCB),使CRM可以作为校准器使用,而不会超过临床样本结果的最大允许的组合标准不确定性 (umaxCS).
主要方法:
- 导出MANCB作为测量参数的umaxCS的一小部分.
- 根据测量程序的精度和非选择性,估计需要的临床样本和CRM测量的数量.
- 制定评估不确定可换性结论和报告评估结果的指南.
主要成果:
- 为评估CRM可交换性,建议使用一个定量标准 (MANCB).
- 该标准与临床样本结果的最大允许的联合标准不确定性 (umaxCS) 有关.
- 提供了基于测量程序特征和所需样本/CRM测量的方法来确定MANCB的适用性.
结论:
- 拟议的MANCB标准提供了一个标准化的方法来评估IVD-MD校准的CRM可换性.
- 这有助于在临床实验室环境中可靠使用CRM,确保诊断测试的准确性.
- 这些建议支持对可换性评估结果进行一致和客观的报告.
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