最近使用外体细胞作为诊断标记物和针对心血管疾病的载体的进展
Ni Li1,2, Tianyuan Zhang2, Linwen Zhu1
1Department of Cardiothoracic Surgery, Ningbo Medical Centre Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315041, China.
Molecular pharmaceutics
|August 11, 2023
概括
外体体显示出作为生物标志物和心血管疾病 (CVD) 的药物载体的希望. 工程外体提供了更好的向和治疗心脏病的潜力,推进心血管疾病治疗策略.
科学领域:
- 生物技术是生物技术.
- 生物医学工程 生物医学工程
- 分子生物学分子生物学
背景情况:
- 心血管疾病 (CVD) 是全球主要的死亡原因.
- 外体,小的细胞外囊泡,表现出固有的心脏向和低免疫性.
- 外体作为诊断生物标志物和药物输送车辆为心血管疾病.
研究的目的:
- 审查外体作为心血管疾病生物标志物的进展和挑战,重点关注非编码RNA.
- 总结工程外体向策略和用于心血管输送的施用方法.
- 讨论用于心血管疾病治疗的基于外体的药物输送的治疗效果和机制.
主要方法:
- 在心血管研究中对外体应用的文献综述.
- 对工程外体修改进行分析,以增强准.
- 在体外和体内研究对基于外体的治疗心血管疾病的评估.
主要成果:
- 外体非编码RNA正在成为新的心血管疾病生物标志物.
- 工程外生体表现出更好的准效率和治疗性交付.
- 外体体显示出作为心血管疾病的药物载体的巨大潜力.
结论:
- 外体构成一个有前途的平台,用于心血管疾病的诊断和治疗.
- 对外体修饰和临床翻译的进一步研究是有必要的.
- 基于外体的疗法为控制心血管疾病提供了一种新的策略.
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