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Updated: Jul 19, 2025

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
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开发一种二基诺林-皮拉林GluN2C/2D-选择性负基调节器的N-甲基-d-酸盐受体

Michael P D'Erasmo1, Nicholas S Akins1, Peipei Ma1

  • 1Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.

ACS chemical neuroscience
|August 11, 2023
PubMed
概括

研究人员开发了一种新化合物, (S) -(-) -2i (DQP-997-74),可选择性抑制特定的N-甲基-D-酸盐受体 (NMDARs),这些受体与神经系统疾病有关. 这种改进的化合物在临床前模型中显示出高选择性和有效性.

关键词:
在NR2C中,它是NR2C.在NR2D中,它是NR2D.血脑屏障 血脑屏障 血脑屏障 血脑屏障是一种.发作 发作 发作结核性硬化综合体 结核性硬化综合体

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