细胞巨乳病毒持续地引发中性粒细胞的氧化爆发
Thomas F Marandu1,2, Michael Dombek1, Michael Gutknecht1
1Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis St., Boston, MA 02215, United States.
Journal of leukocyte biology
|August 11, 2023
概括
慢性细胞巨乳病毒 (CMV) 感染持续增强中性粒细胞的氧化突发和免疫能力强的主体的反应能力. 这种与病毒载荷相关的免疫启动,在急性感染消失后很长时间就会影响中性粒细胞的功能.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 细胞巨乳病毒 (CMV) 是一种广泛传播的疹病毒,具有终身持久性.
- 虽然在免疫抑制个体中已知,但CMV对免疫能力较强的主体的影响不太清楚.
- 冠状病毒影响宿主免疫力,可能提供保护,但也会引起免疫病理.
研究的目的:
- 为了研究慢性细胞巨乳病毒 (CMV) 感染对免疫能力强的主体中中性粒细胞功能的影响.
- 为了确定CMV感染是否导致中性粒细胞响应性的持久变化.
主要方法:
- 利用一种对CMV感染和延迟的小鼠模型.
- 分析了中性粒细胞氧化突发,甲基受体表达,c-Jun N-终端激酶酸化和CD14表达.
- 与病毒载量相关的中性粒细胞原始化.
主要成果:
- 慢性CMV感染持续增强中性粒细胞氧化突发后急性感染.
- 活体中性粒细胞的原始化与增强的甲基受体,构成性JNK酸化和增强的CD14表达有关.
- 中性粒细胞的原始化取决于病毒载量.
结论:
- 慢性CMV感染显著影响免疫能力强的主体中中性粒细胞的反应.
- 这一以前未知的效应突出了CMV相关免疫病理学的潜在机制.
- 人类CMV感染的变异性表明对中性粒细胞初始化的不同影响.
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