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缺血性中风患者的功能性和结构性大脑重组:多模式MRI融合研究

Fangyuan Cui¹, Lei Zhao², Mengxin Lu^1,3

¹Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, No.5 Haiyuncang, Dongcheng District, Beijing 100700, China.

Cerebral cortex (New York, N.Y. : 1991)

|August 11, 2023

概括

脑卒中患者在病变和远部区域显示同步的结构和功能性脑损伤. 在康复过程中,这些模式独立地发生变化,影响运动功能.

科学领域:

神经成像是一种神经成像.
脑卒中研究脑卒中研究
大脑重组大脑重组

背景情况:

脑卒中的诊断和预后依赖于理解大脑的重组.
之前的MRI研究分析了单个模式,使多模式变化和运动缺陷联系不清楚.

研究的目的:

用多式融合研究中风后大脑结构和功能的共同改变模式.
检查这些变化与运动缺陷之间的关系.
为了比较基线和后续会议之间的变化.

主要方法:

招募了71名半患者和41名健康对照 (HC).
利用多式融合 (多式法定关联分析+联合独立组件分析) 以低频波动幅度 (ALFF) 和灰色物质体积 (GMV).
在基线和2周后期进行MRI.

主要成果:

与中风患者相比,中风患者在局部病变和远部区域的脑结构 (GMV) 和功能 (ALFF) 呈现同步下降.
局部损伤区域的损伤与运动功能缺陷相关.
2周后,ALFF在局部病变中增加,但GMV没有改善.

结论:

缺血性中风会导致局部和远部大脑区域的同步结构和功能损伤.
在运动恢复期间,结构和功能变化分开,功能独立于结构得到改善.

关键词:

缺血性中风中风运动缺陷运动缺陷多模式融合融合的多样性这就是重组,重组,重组.

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