阻塞性睡眠呼吸暂停症下综合征皮质区域之间的异常相互作用儿童
Naikai Shi1, Feng Pang2,3,4, Jin Chen1
1Key Laboratory of Brain, Cognition and Education Science, Ministry of Education, China; Institute for Brain Research and Rehabilitation, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, 510631 Guangzhou, China.
Cerebral cortex (New York, N.Y. : 1991)
|August 11, 2023
概括
患有阻塞性睡眠呼吸暂停症候群的儿童表现出大脑网络活动的改变. 这些信息流模式的变化可能成为诊断儿科患者病情的潜在生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 儿科睡眠医学 儿科睡眠医学
- 生物标志物发现发现
背景情况:
- 儿童的阻塞性睡眠呼吸暂停低呼吸综合征 (OSAHS) 损害了认知功能.
- 了解儿科OSAHS中神经网络的改变对于早期诊断和干预至关重要.
研究的目的:
- 为了识别儿科阻塞性睡眠呼吸暂停缺血综合征的潜在脑电图 (EEG) 网络生物标志物.
- 调查与没有OSAHS的儿童之间的皮质信息相互作用和流动模式的差异.
主要方法:
- 利用符号转移来构建有效的大脑网络并评估皮质信息相互作用.
- 分析了信息流动模式,使用交叉内部变化和后置前置信息流量比.
- 在轻度OSAHS,严重OSAHS和健康对照组中,比较了不同睡眠阶段 (N1,N2,N3,REM) 的EEG网络参数.
主要成果:
- 与对照组相比,小儿OSAHS患者在N1,N2和REM阶段表现出显著更高的符号转移 (P<0.05) 和在N3阶段 (P<0.005) 较低.
- 在OSAHS组中,β频段在所有睡眠阶段的交叉内变化显著较低 (P<0.05).
- 轻度OSAHS儿童在REM睡眠期间表现出明显更高的后前信息流在β频段 (P<0.05).
结论:
- 改变了EEG网络动态,特别是信息流和传输,是儿科阻塞性睡眠呼吸暂停症候群的特征.
- 这些独特的网络模式有望成为诊断儿童OSAHS的潜在生物标志物.
- 这些发现为儿童OSAHS认知缺陷背后的神经生理机制提供了新的见解.
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