在老年人住院期间可能不适当使用药物的变化和不良结果之间的关联:一项回顾性研究
Ying-Hsin Hsu1, Ming-Yueh Chou2, Wei-Cheng Chang3
1Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan; Division of Neurology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan.
在住院期间,在老年人中增加潜在不适当药物 (PIM) 显著增加功能衰退,长时间住院和死亡率的风险. 减少PIM对于改善患者的治疗结果至关重要.
科学领域:
- 老年医学 老年医学
- 医院 医院 医疗 医疗 医疗 医疗
- 药理学 药理学是指药理学的学科.
背景情况:
- 潜在不合适的药物 (PIMs) 是老年人关注的一个问题.
- 住院期间PIMs变化的对不良结果的影响需要进一步调查.
研究的目的:
- 评估住院期间老年人PIM数量的变化与不良结果之间的关联.
- 确定与老年患者增加PIM使用相关的风险.
主要方法:
- 在内科病房中对3460名老年成人患者进行了回顾性队列研究.
- 使用酒标准识别的PIM.
- 不良结果包括功能衰退,长时间停留 (LOS) 和死亡率.
主要成果:
- 65.3%的患者在住院期间经历了PIM的增加.
- 增加PIM使用与功能衰退 (aOR1.36),长时间的LOS (aOR3.47) 和死亡率 (aOR2.68) 密切相关.
- 一个显著的趋势 (p<0.001) 显示,随着PIM数量的上升,不良结果的增加.
结论:
- 在住院期间增加PIM的老年人面临更高的功能衰退,长期LOS和死亡风险.
- 患有三种或以上PIM的患者表现出特别高的风险.
- 需要进一步的研究来制定干预措施,以减少PIM和改善结果.
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