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通过影响死,炎症,肠道屏障和肠道菌群,SeNPs减轻了BDE-209诱导的肠道损伤

Zhuoqi Zhang¹, Jianhua Shan¹, Bendong Shi¹

¹College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China.

Ecotoxicology and environmental safety

|August 11, 2023

概括

纳米颗粒 (SeNPs) 通过减少肠道损伤,氧化应激和炎症来保护免受脱甲乙烯 (BDE-209) 的伤害. 此外,SeNP还可以恢复因BDE-209暴露而破坏的肠道微生物群平衡.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
纳米技术纳米技术

背景情况:

聚二乙烯 (PBDE) 是具有毒性和生物累积作用的环境污染物.
纳米粒子 (SeNPs) 具有抗氧化,抗炎和抗毒素的特性.
脱博乙烯 (BDE-209) 暴露可以在生物体中引起肠道损伤.

研究的目的:

评估SeNPs在中对BDE-209引起的肠损伤的保护作用.
为了研究SeNPs对氧化应激,亡,炎症和BDE-209暴露后肠道屏障功能的影响.
评估SeNPs在暴露于BDE-209的中调节肠道微生物群组成和多样性的作用.

主要方法:

60只被分为四个组:对照组,SeNPs,BDE-209和BDE-209+SeNPs.
被暴露在42天的治疗中.
分析了肠道损伤标志物,氧化应激指标,炎症因素,紧结蛋白水平,亡标志物和肠道微生物群组成.

主要成果:

暴露于BDE-209会增加氧化应激 (MDA) 和炎症 (TNF-α,RIPK1,RIPK3,MLKL),并降低抗氧化酶活性 (T-SOD,T-AOC,GSH) 和紧密结合蛋白 (Claudin-1,Occludin,ZO-1).
治疗SeNPs减轻了BDE-209引起的氧化应激,亡,炎症和肠道屏障损伤.
SeNPs恢复了肠道微生物群的α和β多样性,改善了其组成和丰富性,抵消了BDE-209诱导的功能失调.
SeNP的保护作用与MAPK/NF-κB信号通路有关.

结论:

在中,SeNP有效地减轻BDE-209引起的肠壁损伤和肠道微生物群疾病.
保护机制包括减轻肠道氧化应激,亡和炎症.
在家禽中,SeNPs代表了对PBDE毒性的潜在治疗剂.

关键词:

肉肉肉肉肠道屏障肠道屏障肠道屏障肠道菌群是什么意思肠道菌群尸体灭 (Necroptosis) 是一种死亡的过程.聚化二乙烯乙烯的聚化二乙烯.纳米粒子是一种纳米粒子.

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