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晚期胎儿造血失败是由于ZBTB11缺乏导致的,尽管HSC规范丰富

Huimin Cao1,2, Shalin H Naik3,4,5, Daniela Amann-Zalcenstein4,5,6

  • 1Australian Regenerative Medicine Institute, Monash University, Clayton, VIC, Australia.

Blood advances
|August 11, 2023
PubMed
概括

转录因子ZBTB11对于哺乳动物造血干细胞 (HSC) 的增殖和细胞周期调节至关重要. 删除ZBTB11会导致HSC过度规范,干性损失和由于造血失败导致的胚胎死亡.

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