在糖尿病黄斑中使用Conbercept的两种不同的初始治疗方案:来自多中心随机对照研究的12个月结果
Fengmei Ren1, Xiurong Zhang2, Hui Gong3
1Department of Retina, Inner Mongolia Chaoju Eye Hospital, Hohhot 010050, China; Department of Cataract, Ulanqab Chaoju Eye Hospital, Ulanqab 012000, China.
Photodiagnosis and photodynamic therapy
|August 11, 2023
概括
对于糖尿病黄斑 (DME) 的3个和6个初始Conbercept治疗,在12个月内显示出类似的视觉和解剖改善. 六剂疗法趋向于更好的结果,年龄和初始眼睛指标影响了结果.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 糖尿病视网膜病变 - 糖尿病视网膜病变
背景情况:
- 糖尿病黄斑 (DME) 治疗最佳方案和结果预测因素需要进一步调查.
- 目前关于DME治疗有效性和影响因素的证据有限.
研究的目的:
- 为了比较3个对6个初始Conbercept剂量与12个月的DME前期注射 (PRN) 的疗效.
- 确定DME患者视力敏度增长和解剖学改善的预测因素.
主要方法:
- 在成年DME患者中进行前性,多中心的,开放的随机对照研究.
- 随机化为3个或6个初始Conbercept剂量,然后在12个月内注射PRN.
- 光学连贯断层扫描血管学 (OCTA) 用于评估黄斑血管密度;多变量回归分析了结果因素.
主要成果:
- 两种3+PRN和6+PRN疗法都产生了可比的最佳校正视敏度 (BCVA) 增加和解剖学改善 (CMT,FAZ,血管密度).
- 6+PRN组显示出更好的深毛细管变化的趋势 (2.53 ± 5.45%).
- 年龄较大,初始中央黄斑厚度 (CMT) 和状血管区 (FAZ) 区域预测了6+PRN组的视觉结果;糖尿病持续时间影响了3+PRN组的CMT.
结论:
- 3个和6个初始Conbercept加载剂量都在DME中实现了类似的解剖和功能视觉改善.
- 在6+PRN疗法中观察到更好的结果的趋势.
- 年龄较大,初始CMT较高,糖尿病持续时间较长可能会对12个月的临床结果产生负面影响.
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