麻木的神经行为损失预期预测复发刺激药物使用
Leili Mortazavi1, Kelly H MacNiven1, Brian Knutson1
1Department of Psychology, Stanford University, Palo Alto, California.
Biological psychiatry
|August 11, 2023
概括
在损失预期期间,前脑岛的脑活动减弱预示着兴奋剂使用障碍的复发. 这些神经行为标记提供了比单独的自我报告措施更准确的复发预测.
科学领域:
- 神经科学是一个神经科学.
- 成研究 研究成研究
- 精神病学是一个精神病学.
背景情况:
- 兴奋剂使用障碍 (SUD) 的特点是复发率高.
- 研究主要集中在药物使用初始化上,对复发机制的关注较少.
- 了解复发预测因素对于开发有效干预措施至关重要.
研究的目的:
- 调查SUD复发背后的动机过程.
- 评估SUD患者对货币收益和损失的神经行为反应.
- 用多式联络方法识别复发的预测因素.
主要方法:
- 功能磁共振成像 (fMRI) 用于测量大脑对金钱激励和损失的反应.
- 参与者包括SUD和健康对照的排毒患者.
- 一个多式模式的设计在6个月的随访期间结合了脑部成像,结构分析和行为评估.
主要成果:
- 在损失预期期间,前胰岛 (AIns) 活动形的患者更有可能复发.
- 较低的AIns活动与减少对损失线索的负面兴奋以及较慢的回避行为相关.
- AIns的活动与AIns和核 accumbens之间的结构和功能连接有关.
结论:
- 神经行为标志物,特别是麻木的AIns活动,显著预测了SUD的复发.
- 这些标记物在预测复发时实现了72.7%的交叉验证准确性.
- 研究结果表明,模糊的避免动机有助于复发,并可能告知有针对性的干预措施.
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