微量元素对多发性骨髓瘤和癌症过程机制的治疗作用
Kasra Jahankhani1, Niloofar Taghipour2, Mohammad Mashhadi Rafiee3
1Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
概括
铁,和等微量元素对健康和免疫功能至关重要. 本综述探讨了它们在治疗多发性骨髓瘤 (MM) 和其他血液癌症方面的治疗潜力.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 微量元素是对人类生长,健康和免疫系统功能至关重要的微量营养素.
- 血液恶性瘤,如多发性骨髓瘤 (MM),以异常的血细胞发育为特征,并可能影响微量元素水平.
- 血清微量元素水平可能作为瘤严重性的指标,在患有血液癌症的患者.
研究的目的:
- 审查特定微量元素的作用,即铁,和,在多发性髓瘤 (MM) 的背景下.
- 检查这些微量元素对关键生物机制的影响,包括免疫反应,氧化应激和细胞循环调节.
- 探索微量元素作为补充或替代治疗剂在治疗血液恶性瘤的潜力.
主要方法:
- 文献综述专注于研究铁,和的影响.
- 微量元素影响免疫系统,氧化/抗氧化平衡和细胞循环的机制的分析.
- 检查微量元素与血液癌症常规治疗的联合使用.
主要成果:
- 铁,和在免疫系统调节,抗氧化防御和细胞周期控制中起着重要的作用.
- 这些微量元素的变化水平在患有血性恶性瘤的患者中观察到,如MM.
- 补充特定的微量元素可以提高传统疗法的疗效,减少炎症.
结论:
- 微量元素,特别是铁,和,作为血液癌症的预防和治疗剂具有前途.
- 它们调节免疫功能,氧化应激和炎症的能力使它们在治疗多发性骨髓瘤方面具有价值.
- 对微量元素补充剂最佳使用的进一步研究可能会导致改善治疗策略和患者的治疗结果.
相关概念视频
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Metastasis
5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
Drugs that Stabilize Microtubules
2.1K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.1K
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K


