纳米粒子的癌症治疗和毒性前景
Neetika1, Mamta Sharma1, Pankaj Thakur2
1School of Biological and Environmental Sciences, Shoolini University, Solan, 173212, India.
Environmental research
|August 11, 2023
概括
纳米粒子 (NP) 提供了有前途的癌症治疗药物,但面临毒性挑战. 本综述探讨了NP的应用,纳米毒性机制和更安全,更有效的癌症管理的解决方案.
科学领域:
- 纳米技术纳米技术
- 在瘤学瘤学.
- 材料科学 材料科学 材料科学
背景情况:
- 纳米粒子 (NP) 由于可调节性质,被探索为癌症治疗药物.
- 癌症专家为癌症检测,成像,治疗和药物输送提供了新的方法.
- 目前的NP应用由于毒性和低生物相容性而面临限制.
研究的目的:
- 审查各种NP (氧化,氧化,银,金) 在癌症治疗中的使用.
- 要突出NP相关的纳米毒性机制和不良的生物相互作用.
- 讨论癌症管理中可控毒性NP的替代解决方案和未来前景.
主要方法:
- 在癌症治疗学中纳米粒子应用的文献综述.
- 对NP-生物分子相互作用和由此产生的毒性进行分析.
- 探索NP发展的替代策略和未来方向.
主要成果:
- 氧化物,氧化,银和金等NP显示出作为具有药理动力学优势的纳米载体的潜力.
- NP聚合和蛋白质冠状形成可能导致细胞功能障碍和功效降低.
- 显著的NP相关毒性,非目标效应和低生物相容性对患者构成风险.
结论:
- 控制毒性纳米颗粒对于推进癌症治疗学至关重要.
- 了解纳米毒性机制是开发更安全,更有效的纳米工具的关键.
- 未来的研究应该专注于高性能NP,为个性化癌症管理提供量身定制的毒性概况.
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