意大利撒丁岛慢性淋巴细胞白血病的流行病学 (1974-2003)
Giorgio Broccia1, Jonathan Carter2, Cansu Ozsin-Ozler3
1Department of Haematology and Bone Marrow Transplants, Hospital A. Businco, Cagliari, Sardinia, Italy.
Experimental hematology
|August 11, 2023
概括
慢性淋巴细胞白血病 (CLL) 的发病率正在全球上升. 这项在撒丁岛的研究发现,与城市生活,距离医院的距离和木收获相关的CLL率增加,这表明了环境和医疗保健接入因素.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 环境健康 环境健康
背景情况:
- 几十年来,慢性淋巴细胞白血病 (CLL) 的全球发病率一直在增加.
- 这种趋势的驱动因素和地理模式仍然不太清楚,遗传因素是不太可能的解释.
研究的目的:
- 调查1974年至2003年在意大利撒丁岛的CLL发病率.
- 确定与该地区CLL风险相关的社会经济和环境决定因素.
主要方法:
- 利用一个验证的数据库,包括1974年至2003年间诊断的1700例CLL病例.
- 应用贝叶斯方法来空间绘制CLL概率和Poisson回归来进行决定性分析.
主要成果:
- 撒丁岛的标准化发病率为每10万人口5.1,年增长率为5.8%.
- 在城市地区,远离医院 (≥30公里) 的居民,以及高收获率的地区,观察到CLL风险升高.
- 没有发现高发病率地区的显著空间聚类.
结论:
- 观察到的CLL发病率的上升可能受到改善的医疗保健和诊断能力的影响.
- 环境因素,如软木收获,也可能在CLL风险中发挥作用.
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