基于瓜尔的刺激响应水凝,用于持续释放迪克洛芬纳克
Muhammad Anees Ur Rehman Qureshi1, Nasima Arshad1, Atta Rasool2
1Department of Chemistry, Allama Iqbal Open University Islamabad, Pakistan.
International journal of biological macromolecules
|August 11, 2023
概括
这项研究开发了新的石墨烯氧化物增强的瓜尔水凝,用于控制的迪克洛菲纳克释放. 这些生物相容和生物降解材料在治疗炎症和疼痛方面表现有前途.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 开发有效的药物输送系统对于向治疗至关重要.
- 水凝为治疗剂的控制释放提供了潜在的潜力.
- 狄克洛菲纳克是一种广泛使用的非类固醇抗炎药物 (NSAID).
研究的目的:
- 为了合成和表征氧化石烯增强的 guar 和多 (N-乙烯基-2-pyrrolidone) 水凝.
- 为了评估从这些水凝中控制释放的二甲.
- 评估开发的水凝的生物相容性,生物降解性和抗菌性质.
主要方法:
- 溶液造技术用于水凝合成.
- 使用3 - 甘基西三甲西兰 (GLYMO) 进行交叉链接.
- 通过FTIR,X射线衍射,热分析和SEM进行表征.
- 在体外生物降解和细胞活力测试 (HEK-293细胞).
- 对P. aeruginosa和E. coli进行抗菌活性测试.
- 在蒸水和缓冲溶液中进行胀研究.
- 用UV-Vis光谱测量监测的迪克洛芬雅克释放动力学.
主要成果:
- FTIR证实了水凝接口的开发.
- 热分析表明,GLYMO度会影响组件间的作用力.
- 水凝证明了生物降解性和生物相容性.
- GPG-32表现出显著的抗菌活性.
- 根据菲克定律,在蒸水中达到2001% (GPG) 和1814% (GPG-8) 的最大膨胀.
- 在pH 6.0下观察到最佳的胀.
- 在2.5小时内释放出88.7%的二甲.
结论:
- 基于瓜尔的水凝是用于炎症和疼痛管理的无毒,生物相容和生物降解的平台.
- 开发的水凝由于改进的机械性能,显示了充满药物的伤口愈合敷料的潜力.
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