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综述:胚胎干细胞作为动物体内的体外雌同体生产的工具

D E Goszczynski¹, M Navarro¹, A A Mutto¹

¹Instituto de Investigaciones Biotecnológicas "Dr. Rodolfo Ugalde"- UNSAM-CONICET, Buenos Aires CP 1650, Argentina.

Animal : an international journal of animal bioscience

|August 11, 2023

概括

试管婴儿生殖的目标是在实验室中复制精子和卵子的发育. 最近的进展侧重于畜牧业,特别是牛,利用干细胞进行精英遗传学,了解胚胎细胞的发育.

科学领域:

生殖生物学生殖生物学
干细胞科学干细胞科学
畜牧科学畜牧科学畜牧科学

背景情况:

试管体内生育试图复制基于实验室的精子和卵细胞发育.
进化分歧阻碍了在大型哺乳动物中复制小鼠的进步.
在人类,灵长类动物和牲畜中正在研究生殖细胞发育的特定物种差异,以寻找潜在的应用.

研究的目的:

审查与畜牧科学相关的体外体育生成的关键进展.
突出胚胎干细胞在牛中生殖细胞应用的潜力.
讨论物种特异性挑战和大哺乳动物性器官发育的进展.

主要方法:

对最近关于体外性子生成的科学文献的综述.
专注于多能干细胞类型用于生殖系衍生.
分析淋巴细胞内的信号环境.
检查复制生殖细胞发育阶段的实验系统.

主要成果:

鉴定新型多能干细胞,适合在牲畜中进行生殖系衍生.
在淋巴体内影响生殖细胞发育的关键信号通路的表征.
开发实验系统以模拟体外生殖细胞发育的各个阶段.
了解规范大型哺乳动物生殖细胞发育的特定物种因素的进展.

结论:

试管体内游戏生成的进步为牲畜,特别是牛遗传学提供了有前途的应用.
胚胎干细胞是培养体外生殖细胞的宝贵平台.
对物种特异性机制的进一步研究对于在大型哺乳动物中复制游戏生成至关重要.

关键词:

游戏发生的过程 (Gametogenesis)胚胎细胞是发生在胚胎中的胚胎细胞.这是Gonads的Gonads.在体外繁殖.多能性是一种多能性.

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