相关实验视频

Updated: Jul 19, 2025

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

Transgenic Rodent Assay for Quantifying Male Germ Cell Mutant Frequency

Published on: August 6, 2014

评论:影响公牛生育能力的基因突变

Hubert Pausch¹, Xena Marie Mapel¹

¹Animal Genomics, Department of Environmental Systems Science, ETH Zurich, Universitaetstrasse 2, 8092 Zurich, Switzerland.

Animal : an international journal of animal bioscience

|August 11, 2023

概括

牛遗传学揭示了影响男性生育能力的关键基因. 识别基因变异有助于提高人工授精的成功率,避免在繁殖计划中生育不良的公牛.

科学领域:

动物遗传学动物遗传学
生殖生物学生殖生物学
量化遗传学量化遗传学

背景情况:

由于广泛的基因组和表型数据,牛作为研究男性生殖表现的有价值的模型生物.
牛的人工授精和基因组预测为生育特征的遗传分析提供了大量数据集.

研究的目的:

识别导致公牛雄性生殖表现变化的遗传因素.
调查单一性生殖障碍和定量生育特征的遗传基础.

主要方法:

全基因组关联测试 (GWAS) 使用微阵列衍生的基因型和详细的精液质量/精液成功表型.
病例控制关联测试用于识别对单基生殖障碍负责的等位基.
使用重复测量精液质量的差异成分估计.

主要成果:

鉴定出了多个单一性生殖障碍的因果递归功能丧失等位基因,现在在繁殖公牛中进行监测.
全基因组关联研究确定了与男性生育能力相关的定量特征位置 (QTL),尽管基本的因果变异在很大程度上仍未知.
确定的QTL仅解释了男性生育能力的总遗传率的一小部分.

结论:

牛的基因分析成功地确定了导致生殖障碍的特定等位基因,并突出了QTL的生育能力.
进一步整合omics数据 (基因表达等) 与GWAS相关的研究对于精确地绘制潜在的男性生育特征的定量因果变异至关重要.
监测基因变异有助于提高人工授精的效率和整体群体的生殖性能.

关键词:

关联测试关联测试关联测试牛群是牛群,牛群是牛群,牛群是牛群.原因变异的原因变异.授精成功授精成功精液质量精液质量

更多相关视频

Mutagenesis and Analysis of Genetic Mutations in the GC-rich KISS1 Receptor Sequence Identified in Humans with Reproductive Disorders

Mutagenesis and Analysis of Genetic Mutations in the GC-rich KISS1 Receptor Sequence Identified in Humans with Reproductive Disorders

Published on: September 4, 2011

Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes

Analysis of Chromosome Segregation, Histone Acetylation, and Spindle Morphology in Horse Oocytes

Published on: May 11, 2017

相关概念视频

Mutation, Gene Flow, and Genetic Drift

Mutation, Gene Flow, and Genetic Drift

In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).

Incomplete Dominance

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.

Meiosis I

Meiosis I

Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...

Nondisjunction

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers. Nondisjunction is common during anaphase I or anaphase II of meiosis. Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...

Infertility in Males

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

Animal Mitochondrial Genetics

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...