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纳米悬浮封装的奇托-pectin微粒作为一种新型的交付平台,用于增强口服生物利用性

Sunitha Sampathi¹, Chormale Jaydeep Haribhau², Vijaya Kuchana³

¹GITAM School of Pharmacy, GITAM Deemed to be University, Rudraram, Hyderabad, Telangana, India.

Carbohydrate polymers

|August 11, 2023

概括

这项研究开发了新型的黄素微珠 (CUR-NS-MB),以提高溶解度和结肠特异性输送. 改进的配方在动物模型中显著增加了黄素的生物可用性,证明了其作为有效的结肠特异性药物递送系统的潜力.

科学领域:

制药科学制药科学
药物输送系统药物输送系统
纳米技术纳米技术

背景情况:

黄素 (CUR) 具有较差的溶解性和有限的结肠特异性输送.
开发有效的传递系统对于增强CUR的治疗潜力至关重要.

研究的目的:

为了制定和优化素纳米悬浮剂 (CUR-NS) 封装成微粒 (CUR-NS-MB).
为了实现提高溶解度和CUR的结肠特异性输送,CUR.
评估开发的CUR-NS-MB的体外和体内性能.

主要方法:

用于CUR-NS配方的抗溶剂沉方法.
使用化用于CUR-NS-MB封装的离子热.
添加了pectin,chitosan和纤维素酸 (CAP) 以控制释放和酸性保护.
粒子大小,表面形态,捕获效率和药物负载的表征.
在不同的pH值下进行体外药物释放研究.
在动物模型中的体内药理动力学研究.

主要成果:

优化纳米悬浮 (用HPMC E-15稳定) 的颗粒大小为193.5 ± 4.31 nm,PDI为0.261 ± 0.020.
优化的CUR-NS-MB实现了89.45 ± 3.11%的捕获效率和14.54 ± 1.02%的药物负载.
该配方在体外药物释放中证明结肠特异性,绕过在酸性条件下降解.
在体内研究显示,与普通CUR相比,Cmax增加了2.5倍,AUC0-48h增加了4.4倍.

结论:

开发的CUR-NS-MB系统有效地克服了CUR的溶解性差,并实现了结肠特异性输送.
该配方表现出增强的体外释放特征和优越的体内药理学参数.
作为一个先进的结肠特异性药物输送平台,CUR-NS-MB具有显著的潜力.

关键词:

基托桑是一种酸盐.库尔库明是一种黄素.微型子是微型子的一种.这是一种纳米悬浮.质素 (Pectin) 是一种可怕的物质.药理动力学药理动力学

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