黄素对血压的影响:系统性审查和剂量反应元分析
Arash Karimi1, Arezoo Moini Jazani2, Melika Darzi3
1Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran; Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tabriz, University of Medical Sciences, Tabriz, Iran.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|August 11, 2023
概括
黄素补充剂对整体血压没有显著影响. 然而,长期使用 (≥12周) 可能会改善腹压血压,特别是在女性中.
科学领域:
- 营养科学 营养科学
- 心血管健康 心血管健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 高血压是一个全球性的健康问题.
- 黄中的活性化合物黄,已经证明具有抗炎和抗氧化特性.
- 它对血压的潜在影响需要调查.
研究的目的:
- 系统地审查和分析关于黄素对缩血压 (SBP) 和腹缩血压 (DBP) 的影响的临床试验.
- 进行剂量反应分析,以探索黄素剂量/持续时间和血压变化之间的关系.
主要方法:
- 在多个数据库中进行了全面的文献搜索,直到2022年11月.
- 包含1377名参与者的17项研究被纳入了元分析.
- 根据补充剂的持续时间和参与者的人口统计数据进行了子组分析.
主要成果:
- 总的来说,黄素补充剂对SBP或DBP没有显著影响.
- 剂量反应分析表明,黄素剂量/持续时间和血压降低之间没有显著的关联.
- 亚组分析显示,补充≥12周的DBP显著降低 (p=0.03) 和女性研究的SBP和DBP显著降低 (p<0.01).
结论:
- 黄素补充剂可能会改善腹压血压,长期使用 (≥12周).
- 专注于女性的研究显示,缩和放缩血压的显著降低.
- 需要进一步的临床试验来验证这些具体发现.
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