从2010年到2021年,在日本的纯种马中感染了Clostridioides difficile感染
Eri Uchida-Fujii1, Hidekazu Niwa2, Mitsutoshi Senoh3
1Microbiology Division, Equine Research Institute, Japan Racing Association, Shiba 1400-4, Shimotsuke, Tochigi, 329-0412, Japan.
Scientific reports
|August 11, 2023
概括
在日本纯种马中,Clostridioides difficile感染 (CDI) 的死亡率很高. 早期诊断和甲尼达治疗显著改善了结果,强调了感染控制的必要性.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 传染性疾病 传染性疾病
- 马的健康 马的健康
背景情况:
- 艰难杆菌感染 (CDI) 对日本的纯种马构成重大威胁.
- 这种人群中CDI的风险因素和预后指标尚不清楚.
- 在2010年至2021年期间,在34例病例中观察到高死亡率 (79.4%).
研究的目的:
- 调查Clostridioides difficile菌株的遗传特征,这些菌株与马类感染有关.
- 确定风险因素,了解C. difficile基因型与纯种马的预后之间的关系.
- 评估治疗,特别是甲尼达对CDI结局的影响.
主要方法:
- 在日本纯种马中对34例Clostridioides difficile感染病例进行了回顾性分析.
- 对C. difficile分离物的基因分析,包括聚合酶连锁反应核型化 (RT) 和二进制毒素 (CDT) 检测.
- 基于治疗 (美特罗尼达) 和C. difficile菌株类型 (RT078,RT014,CDT阳性) 的死亡率的比较.
主要成果:
- 聚合酶连锁反应 рибо型 (RT) 078 是主要的基因型 (35.3%),其次是RT014 (17.6%).
- 在16匹马中发现了二进制毒素 (CDT) 阳性菌株,包括所有RT078分离物.
- RT078或CDT阳性菌株的死亡率与其他类型相比.
- 与未经治疗的病例 (100%) 相比,甲尼达治疗与显著较低的死亡率 (65.0%) 相关.
结论:
- 甲尼达治疗对于改善CDI纯种马的存活率至关重要.
- 虽然像RT078和CDT阳性菌株这样的特定基因型很常见,但与其他类型相比,它们并没有显著改变死亡率.
- 加强感染控制措施和快速诊断能力对于在马群中管理CDI至关重要.
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