在一般人口样本中,慢性并发症和喘恶化发生
Emma Baljet1, Hilde Luijks1,2, Lisette van den Bemt1
1Department of Primary and Community Care, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
NPJ primary care respiratory medicine
|August 11, 2023
概括
慢性疾病,如肥胖和类风湿性关节炎增加严重的喘恶化. 脑卒中和类风湿性关节炎的病史也会在患有喘的成年人中增加中度恶化风险.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 内部医学 内部医学
背景情况:
- 慢性伴随性疾病在患有喘的成年人中很普遍.
- 这些并发症可能会显著影响喘恶化风险.
- 了解这些关联对于有效的喘管理至关重要.
研究的目的:
- 调查18种慢性并发症和成人喘恶化发生之间的关联.
- 为了确定与中度或重度喘恶化风险增加相关的特定并发症.
- 根据并发症条件,为个性化喘管理策略提供信息.
主要方法:
- 在使用美国国家健康和营养检查调查 (NHANES) 数据 (2007-2018) 的队列内嵌入的横截面研究.
- 包括2387名自我报告医生诊断的当前喘的成年人.
- 顺序逻辑回归分析被用来估计喘恶化的几率比率 (OR),调整为混因素.
主要成果:
- 肥胖 (OR=1.67) 和类风湿性关节炎 (OR=1.55) 与严重喘恶化增加有关.
- 史上的中风 (OR=1.95) 和类风湿性关节炎 (OR=1.33) 与中度喘恶化增加有关.
- 年龄分层分析显示了软药使用,肥胖,抑郁,甲状腺问题和类风湿关节炎与不同年龄组恶化之间的关联.
结论:
- 几种慢性并发性疾病与成人喘恶化发生有显著的关联.
- 这些发现证实并扩展了关于伴随性疾病和喘的先前研究.
- 这些结果有助于完善喘恶化风险评估,并支持个性化患者管理.
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