婴儿与母亲对SARS-CoV-2的高结合性和功能性抗体反应
Caitlin I Stoddard1, Kevin Sung2, Zak A Yaffe1,3
1Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Nature communications
|August 11, 2023
概括
婴儿与成年人相比,具有明显的严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 抗体反应. 婴儿表现出更高的结合抗体和抗体依赖细胞细胞毒性 (ADCC),但具有类似的中和活性.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 儿科 儿科 儿科
背景情况:
- 婴儿对病毒感染的免疫反应,包括SARS-CoV-2,与成年人不同.
- 关于婴儿的SARS-CoV-2抗体特异性和功能的数据有限,与成人直接比较很少.
研究的目的:
- 描述和比较SARS-CoV-2抗体结合和功能在感染婴儿与他们的母亲.
- 为了研究与SARS-CoV-2相对幽默免疫力的年龄相关差异.
主要方法:
- 对36名感染SARS-CoV-2的母亲和14名婴儿的康复血进行分析.
- 对SARS-CoV-2的抗体标位测量尖端,受体结合域 (RBD) 和N端域 (NTD).
- 对抗体依赖细胞细胞毒性 (ADCC) 和伪病毒中和的评估.
主要成果:
- 与母亲相比,婴儿对SARS-CoV-2 Spike,RBD和NTD的抗体标位明显更高.
- 婴儿和母亲都有针对类似的Spike S2区域的抗体,但婴儿在融合 (FP) 中显示出更高的水平和更多的逃生途径.
- 婴儿表现出明显更高的ADCC活性,而斯派克伪病毒中和标位在婴儿和母亲之间是相似的.
结论:
- 与成年人相比,婴儿发展出不同的SARS-CoV-2结合和功能抗体概况.
- 对SARS-CoV-2感染的幽默免疫力的年龄相关差异在婴儿中很明显.
- 这些发现可能对了解婴儿的保护和COVID-19疾病结果产生影响.
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