瘤相关巨细胞中的JMJD6通过STAT3/IL-10轴调节巨细胞极化和癌症进展

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Updated: Jul 19, 2025

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Siyuan Chen1, Manni Wang1, Tianqi Lu1

  • 1Laboratory of Aging Research and Cancer Drug Target, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, No.17, Block3, Southern Renmin Road, Chengdu, Sichuan, 610041, People's Republic of China.

Oncogene
|August 11, 2023
PubMed
概括

含Jumonji域6 (JMJD6) 调节与瘤相关的巨细胞 (TAMs). 抑制JMJD6可以逆转免疫抑制的TAM,增强癌症治疗和免疫检查点阻塞的有效性.

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