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间歇性禁食激活了巨细胞迁移抑制因子,并缓解了高脂肪饮食引起的非酒精性脂肪肝疾病

Dezhao Li¹, Yaoshan Dun^1,2, Dake Qi³

¹Division of Cardiac Rehabilitation, Department of Physical Medicine and Rehabilitation, Xiangya Hospital Central South University, Changsha, Hunan, China.

Scientific reports

|August 11, 2023

概括

间歇性禁食 (IF) 和正常饮食 (ND) 改善了小鼠的非酒精性脂肪性肝病 (NAFLD). 通过激活巨细胞迁移抑制因子 (MIF) /AMPK通路,增强自和亡调节,IF显示出卓越的疗效.

科学领域:

肝病学肝病学是一种肝病学.
代谢障碍代谢障碍代谢障碍
细胞生物学细胞生物学

背景情况:

高脂肪饮食 (HFD) 诱导的非酒精性脂肪性肝病 (NAFLD) 是一个日益严重的健康问题.
正常饮食 (ND) 是标准疗法,但间歇性禁食 (IF) 可能提供更强大的治疗益处.
了解NAFLD治疗背后的分子机制对于开发有效干预措施至关重要.

研究的目的:

在小鼠模型中研究和比较ND和IF对HFD诱导的NAFLD的治疗效果.
探索潜在的分子机制,包括脂质代谢,亡和自.
为了确定IF在治疗NAFLD方面是否表现出比ND更高的疗效.

主要方法:

在小鼠中使用10周的HFD诱导NAFLD.
随后,小鼠在12周内继续接受HFD,ND或IF治疗.
分析了肝脏组织的脂质沉积,新陈代谢,亡和自. 还测量了血糖和胰岛素水平.

主要成果:

两种IF和ND治疗都改善了NAFLD小鼠的脂质沉积和代谢障碍.
IF和ND减轻了体重增加,肝脏体重增加和HOMA-IR指数.
IF和ND激活了巨细胞迁移抑制因子 (MIF) /AMPK通路,调节下游自和亡,IF显示出更大的有效性.

结论:

IF和ND都激活了MIF信号,减轻了NAFLD相关的脂毒性.
在治疗NAFLD方面,间歇性禁食比正常饮食更有效.
对MIF的差异上调可能解释了IF在NAFLD治疗中的优越优势.

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